Monday, March 9, 2020
Media & Culture - Sign Symbol Essays - Philosophy Of Language
Media & Culture - Sign Symbol Essays - Philosophy Of Language Media & Culture - Sign Symbol A sign system is representation through communication which in turn leads to a shared meaning or understanding. We hold mental representations that classify and organise the world (whether fact or fiction), people, objects and events into meaningful categories so that we can meaningfully comprehend the world. The media use sign systems through newspapers, magazines, television,internet, and the radio etc. The conceptual map of meaning and language are the basis of representation. The conceptual map of meaning, are concepts organised, arranged and classified into complex relations to one another. The conceptual map of meaning although allows you to distinguish your own individual interpretation of the world, at the same time as holding similar views to that of other people in your culture. As the meaning is produced and constructed and in turn learned by a particular group of people. Therefore sharing conventions and codes of their language and culture. Signs can only convey meaning if we possess codes which allow us to translate our concepts into language. These codes are the result of social conventions which lead to the shared maps of meaning. These shared meanings are learnt unconsciously as we become members of a culture.If we have a concept of something in our minds we can say we know the meaning of this concept. However we cannot express or communicate this meaning without the second system of representation, language. Language is the only way in which meanings can be effectively exchanged between people, as people within the same culture are able to interpret the sign of language in the same manner. As the meanings become natural through the conditioning of culture. For example the word white in Australia represents a colour of purity, however in China it is the colour of death. Demonstrating that different cultures have not only have different meanings in their shared conceptual maps, but a different language to express it. As meanings change rapidly throughout cultures to really understand another culture you must live there and speak the language for some time. Cultural, social, political, and linguistic conventions are learned over time. The three theories of representation, reflective, intentional and constructionist approaches explain how representations through language work. The reflective approach is where language functions as a mirror of the particular elements perceived meaning. The intentional approach, is where the authors individual views of the world are expressed. Whereas the constructionist approach is where we the audience construct the meaning through our shared conceptual maps and language. The media use these sign symbols so that an association can be made to the object, person, event, or idea etc. With this information of representation and language the media can familiarise people with many things, such as cultural knowledge. As advertising surrounds consumers, concern is often expressed over the impact on society, particularly on values and lifestyle. While a number of factors influence the cultural values, lifestyles, and behaviour of a society, the overwhelming amount of advertising and its prevalence in the mass media suggests that advertising plays a major role in influencing and transmitting social values. In his book Advertising and Social Change, Ronald Berman says; The Institution of the family, religion and education have grown noticeably weaker over each of the past three generations. The world itself seems to have grown more complex. In the absence of traditional authority, advertising has become a kind of social guide. It depicts us in all the myriad situations possible to a life of free choice. It provides ideas about style, morality, and behaviour. While there is general agreement that advertising is an important social influence agent, opinions as to the value of its contribution are often negative. Advertising is criticised for encouraging materialism, manipulating consumers to buy things they do not really need, perpetuating stereotyping, and controlling the media. The media must consider the cultural variables of each country, such as the complexity of learned meanings, norms, language, customs, tastes, attitudes, religion, traditions, education, lifestyle, values, and the ethical/moral standards shared by members of each society. These variables must be learnt by the media as not to offend the group they are portraying. Cultural norms and values offer direction and guidance to members of a society in all aspects of
Saturday, February 22, 2020
6. To what extent were womens lives transformed by obtaining the vote Assignment
6. To what extent were womens lives transformed by obtaining the vote in 1918 and 1928 - Assignment Example They had no right for electoral positions in the parliament, and they were also not permitted to vote. It was presumed that women were not required to vote since their husbands took that responsibility on their behalf. Womenââ¬â¢s responsibility was taking care of the home and childbearing. During industrial revolution, women became full- time employees which implicate that they had no opportunities to meet in groups to discuss social and political issues. In 1866, organized campaigns for women suffrage started to appear and from 1888, women were allowed to vote in local council elections. John Stuart proposed an amendment that women should be permitted to vote just as men but unfortunately rejected. Voting for women was always considered as an improvement in womenââ¬â¢s rights. Many women viewed a vote as an outstanding achievement as that would give them a voice in the laws that were affecting their lives (Lambert, 2015, p.22). For years, women have struggled to achieve equal representation and rights in official activities. The quest for equality accelerated in the 19th century. This is the period when men became actively involved in wars as there was tension all over the world. While their men were away, women served the nation, and they did menââ¬â¢s work in various ways. In 1918, the passed a law that the women should be given a right to vote. This was as a result of the ability they had shown during the period in which their men were away. More women were willing to volunteer to work in ammunitions manufacturing factories, others were willing to take even significant risks being nurses for the wounded soldiers, and others became secretaries and assistants in offices that were used to control war troops among other important roles. Almost every individual who supported the motion of women to obtain voting right plainly said that they deserved it due to their courageous conduct during the period of war. Supporters of
Wednesday, February 5, 2020
Money and banking Research Paper Example | Topics and Well Written Essays - 1000 words
Money and banking - Research Paper Example Despite the governmentââ¬â¢s efforts to prevent the collapse of the banking system, it did not successfully restore economic growth; the United States entered a deep recession in December 2007 that extended up to June 2009 (Kroszner and Melick 6). FED used the three tools of monetary control: open market operation, reserve requirement, and discount rate to counteract the progression of the financial crisis. Figure 1: The Graph showing the financial crisis between 2007 and 2007 (Source: Gowland 33) The graph above shows that there was constant recession between 2007 and 2009. Financial recovery began to be experienced as from march 2009. Open market operation The most appropriate monetary policy that was used to counter the financial crisis of 2007-2009 constituted the increase the monetary base. Open market operation (OMO) is an instrument of monetary policy, which involves selling and purchasing of marketable securities (Stock and Mark 11). These transactions are conducted in the open market by the central bank as an instrument of controlling the monetary system. Open market operations target the cash balances of held by commercial banks and other non-bank financial institutions including their tills and in relation to their excess reserves at the central bank. The central bank sells its holdings of the government securities to commercial banks to reduce excess reserve held by commercial banks. When the central bank anticipates liquidity deficiency, it injects additional liquidity by purchasing from the existing stock of the government securities. Decreasing the monetary base during the 2007-2009 financial crisis involved the reduced supply of credit, which was used to facilitate the adjustments in financial market in order to achieve equilibrium in money demand and supply. The Federal Reserve had to sell large quantities of securities that were necessary to achieve decreased supply of credit (Stock and Mark 22). Fed would also sold high-quality securities to minimize Fedââ¬â¢s credit risk and the public would be informed that the expansion in the monetary base is temporary; thus, the composition of Federal Reserveââ¬â¢s balance sheet and size of the monetary base would be restored to normal after financial markets and economic activity begin to normalize. The Federal Reserve used the tool of open market operations with an objective of supporting proper functioning of credit markets, reduce the pressure on long-term financial markets and make financial conditions accommodative by selling long-term securities for the Fedââ¬â¢s portfolio. Figure 2: The Open Market Operations Graph (Source: Stock and Mark 21) i represents the nominal rate of interest, Dm represents money demanded and Ds represents the money supplied. The Federal Reserve varies the rates of interest to ensure maintenance of demand and supply of money with the aim of preventing financial crises. Discount Rate The second tool of monetary control that Fed used durin g the financial crisis is the discount rate. Under this policy, the bank can borrow reserves from the Federal Reserve at their discount windows (Stock and Mark 18). These rates are set by the Boards of Directors of the Reserve Banks, but the rates must be subjected to determination and review by the Federal Reserve Board. The Federal Rese
Tuesday, January 28, 2020
G-protein Cycle and its Regulation by RGS Proteins
G-protein Cycle and its Regulation by RGS Proteins Julia Weigandt G Proteins, also known asguanine nucleotide-binding proteins, are a family of membrane resident ââ¬Å"go-betweenâ⬠proteins that are important molecular switches in the mediation of GPCR signalling1. In their inactive state, G-proteins exist as heterotrimeric complexes composed of à ±, à ² and à ³-subunits. Upon its stimulation, a GPCR will catalyse the GDPà ¯Ãâà GTP exchange at Gà ± leading to the dissociation of the trimer complex as a Gà ±-subunit and the Gà ²Ã ³-dimer, both able to interact with a number of effector systems responsible for cellular responses. Upon hydrolysis of GTP to GDP+P by Gà ±, the G-protein mediated signalling is terminated, whereby a group of proteins, the regulators of G-protein signalling (RGS) appear to play substantial role1,2. Every organ system utilises G-protein mediated signal transduction evoking such diverse outcomes as neurotransmission, immunity, cardiovascular function and hormone secretion3. Consequently, GPCRs present a variety of opportunities as therapeutic targets for treating cancer, cardiac dysfunction, central nervous system disorders and pain. In fact, drugs targeting members of this protein superfamily account for 40% of all prescription pharmaceuticals on the market2. GPCRs constitute the largest and most diversefamily of heptahelical transmembrane receptorsà that receive a signal (e.g. small peptides, lipid analogues, amino-acid derivatives, and sensory stimuli such as light, taste and odour2)from outside thecelland transmit this signal to the cell interior via interactions with G-proteins leading to activation of downstream effector systems4. In mammals 21 Gà ±-subunits, six Gà ²-subunits and twelve Gà ³-subunits have been described5. Depending on their Gà ± similarity, G-proteins are grouped into four main classes: Gà ±s, Gà ±i/o, Gà ±q/11 and Gà ±12/13 which show selectivity with respect to both, receptors and effectors due to the presence of recognition domains complementary to G-protein binding domains in receptors/effectors6. The main targets for G-proteins include adenylyl cyclase, phospholipase isoforms, Rho A/Rho kinases (a system that controls mainly signalling pathways involved in cell growth/proliferation), and the mitogen a ctivated protein kinase (involved in the control of many cell functions such as cell division), and ion channels7,8. In its inactivated state the complex is freely diffusible in the plane of the cell membrane due to fatty acid chain anchors on each subunit7. Stimulation of GPCRs by agonists leads to conformational changes in the receptor resulting in the acquirement of high affinity to the G(à ±Ã ²Ã ³) complex. Due to their subsequent association, a GDP->GTP exchange in the à ±-subunit will occur leading to dissociation of the G-protein complex from the receptor in form of a Gà ±(GTP)-subunit and a Gà ²Ã ³-dimer. Prior the activation of the G-protein the Gà ²Ã ³-dimer is bound to a hydrophobic pocket present in Gà ±-GDP. GTP binding to Gà ± removes the hydrophobic pocket and reduces the affinity of Gà ± for Gà ²Ã ³9. Both have a signalling function and can interact with various downstream effector systems 7,9. The duration of G protein-mediated effector activation is dependent on the intrinsic GTPase activity of the Gà ±-subunit. GTP-hydrolysis results in dissociation of Gà ±(GDP) f rom the effector to reunite with Gà ²Ã ³ completing the cycle7. Several studies have shown that the kinetics of G-protein signalling are regulated by RGS proteins that can not only act as GTPase activating proteins (GAPs) on Gà ±-subunits hereby accelerating GTP-hydrolysis, but also as scaffolds to help assemble signalling complexes and providing a critical mechanism of regulation of cellular responses10. Over 30 RGS/RGS-like domain containing proteins have been described and classified into nine distinct subfamilies based on primary sequence homology and presence of additional domains, including the A/RZ (prototype RGSZ), the B/R4 (prototype RGS4), the C/R7 (prototype RGS7), the D/R12 (prototype RGS12), the E/RA (prototype Axin), the F/GEF, G/GRK, H/SNX and I/D-AKAP2 subfamilies3,10,11. They differ widely in their overall size and amino acid identity, and many family members possess a remarkable variety of structural domains and motifs that regulate their actions and/or enable them to interact with other binging partners with diverse cellular roles. RGS proteins have a highly conserved RGS domain of 120 amino acids3,11 which allows for selective binding to the transition state of Gà ±(GTP->GDP+P)8 , accelerating the GTP-hydrolysis up to a 1000-fold5,10 by stabilising this transition. Some studies have shown that RGS proteins can also act as effector antagonists by binding tightly to Gà ±(GTP), hereby blocking effector activation5,11. It has been suggested that simple RGS proteins (those of A/RZ and B/R4) have an almost exclusively negative regulatory function acting as modulators of G-protein signalling as for instance shown by the function of RGS4, an effective GAP protein for Gà ±q family members. In mammalian cells RGS4 doesnââ¬â¢t block the receptor and Gà ±q/11-directed inositol lipid/Ca2+ signalling completely but elicit rhythmic Ca2+ oscillations in mammalian cells10, 11. On the contrary, the larger RGS proteins can link active Gà ±s to other signalling pathways and therefore serve as multifunctional integrators. Integration can occur via activation of kinases, recruitment of cellular scaffolds/associated proteins or by direct receptor interactions11. Two of the R12 family members (RGS12 and RGS14) were shown to coordinate components of the Ras/Raf/mitogen-activated protein kinase signalling pathway8,10. RGS proteins display specificity and selectivity in their interactions not only with G-proteins, but also GCPRs, ion channels and other signalling events3,5 which may be accomplished by firstly, differences in GAP activity towards different types of Gà ±-subunits (e.g. RGS19 was shown to interact strongly with Gà ±i1, Gà ±i3 and Gà ±o, weakly Gà ±i2 but not with Gà ±s and Gà ±q5; secondly, the ability to interact with specific GPCRs or with effectors within the GPCR signalling axis directly, due to presence of characteristic structural domains and motifs (e.g. RGS2 and RGS4 bind selectively the 3rd intracellular loop of M2 and M5 muscarinic receptors5); thirdly, by formation of an RGS/G-protein complex that prevents the G-protein from binding its receptor or the downstream effectors; and lastly, by co-expression of the RGS-proteins with its target protein(s) in order for selective interactions to take place. An example is illustrated by the expression of the alternative splice d RGS9-1 and RGS9-2 in entirely different tissues, thus having different functions and selectivity for different targets. While RGS9-1 is expressed in the photoreceptor cell layers of the retina and is involved in the phototransduction pathway by regulation of photoreceptors, RGS9-2 is predominantly found in the brain and shows selectivity for the regulation of dopamine D2 and opioid à µ receptor signalling pathways5. RGS proteins play and essential regulatory role in G-protein mediated signal transduction, being able to regulate a great number of GCPR signalling events with great specificity and accuracy. By fully understanding the mechanisms and the significance of their expression, role and targets it can lead science to advances in the development of novel therapeutic drugs against disorders involving G-protein mediated signalling. References Baltoumas, F. A., Theodoropoulou, M. C., Hamodrakas, S.J.; Interactions of the a-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials. Journal of Structural Biology.2013;(182):209-218 Filmore, D.; Its a GPCR world. Modern Drug Discoveryà (American Chemical Society).2004; (November): 24ââ¬â28 Bansal, G., Druey, K.M., Xie, Z.; R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacology and Therapeutics. 2007;116(3):473-495 Joost, P., Methner, A.; Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands.Genome Biology. 2002;3(11): research0063.1ââ¬â0063.16 Xie, G.X., Palmer, P.P.; How regulators of G protein signaling achieve selective regulation. Journal of molecular biology. 2007;366(2):349-365 CABRERA-VERA, T.M., VANHAUWE, J., THOMAS, T.O., MEDKOVA, M., PREININGER, A., MAZZONI, M.R., HAMM, H.; Insights into G Protein Structure, Function, and Regulation.à Endocrine Reviews. 2003;24(6):765-781 Rang, H.P., Dale, M.M., Ritter, J.M., Flower, R.J., Henderson, G.; Rang and Dales Pharmacology. 7th ed. UK. Elsevier Churchill Livingstone ; 2012; 3(32-33) Kimple, A.J., Bosch, D.E., Giguà ¨re, P.M., Siderovski, D.P.; Regulators of G-protein signaling and their Gà ± substrates: promises and challenges in their use as drug discovery targets. Pharmacological Reviews. 2011;63(3):728-749 Oldham, W.M., Hamm, H.; Heterotrimeric G protein activation by G-protein-coupled receptors.NATURE REVIEWS | molecular cell biology. 2008;9:60-71 Keinan, D., Yang, S., Cohen, R.E., Yuan, X., Liu, T., Li, Y.P.; Role of regulator of G protein signaling proteins in bone.Front Biosci (Landmark Ed). 2014;1(19):634-648 Hollinger, S., Hepler, J.R.;. Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.Pharmacological Reviews. 2002;54(3):527-559
Monday, January 20, 2020
Population Structure and Economic Implications of Kenya and China :: Papers
Population Structure and Economic Implications of Kenya and China In this piece of text I will be analysing and comparing the population structure and economic implications of two countries. The two countries that I have chosen are Kenya and China. China is a mixture of an LEDC and an MEDC whilst Kenya is a LEDC. You will be able to notice the difference when I give the facts and details of both countries. Population structure is such things as death rate and also birth rate and population spreads. It also shows the amount of people that are a certain age. The pyramid can also show the different trends and patterns of the age groups. Economic implications are the work force of the country and the industries in the countries. Country Status ============== China is a mixed between and LEDC and MEDC as said earlier, this is because the countries has a mixture of areas where some people are not as fortunate as others. The population of this country is around 1.3 billion. By looking at the map below you can see that it takes up a large space of Asia so there is no surprise that there is a lot of people living in the country. Here is a map to show where China is. [IMAGE] [IMAGE] Kenya on the other hand is an LEDC suffering from hunger, disease and dehydration. Kenyaââ¬â¢s population is around 32 million which is much lower than China because of different death rates birth rates, infant mortality which will be explained later. Here is a map to show where Kenya is situated. A complete opposite to China in population size and status of the country. Death Rate ========== In China there is a small death rate of 7 per 1000 which is very low. The death rate is low because of reasons such as there is good health facilities which obviously means that people can be treated better
Sunday, January 12, 2020
Christian Worldview Essay
Worldview Part I What is a worldview? ââ¬Å"A worldview, is a response of our heart or inner being; our intellect, emotion or will. It is the total framework we bring to decision-makingâ⬠(Weider & Gutierrez, 2011, p.51). An example is the Christian worldview. The way we as Christians behave should be in direct correlation with the teachings of Jesus as to how we should live our lives. People who hold to the Christian worldview should act as if everything they do matters. Many Christians these days do not act in a consistent manner to what their worldview is (Keener). Part II The question of Origin, Genesis 1:1 (ESV Bible) shows God creating the heavens and the earth in the beginning. ââ¬Å"God is the infinite, personal, sovereign and good being who created the universeâ⬠(Lefebvre, 2011). Isaiah 45:18 (ESV Bible) describes how God created the heavens and formed the earth and create it and intended it to be inhabitated. The question of Identity- Genesis 1:27(ESV Bible) God created man in His own image. Psalm 139:14(ESV Bible) I am fearfully and wonderfully made. It is because we are made in Godââ¬â¢s image that sets us apart from all other aspects of creation. This identity with God bestows upon us great distinction. We have to understand as clearly as possible what it means to be created in the image and likeness of God (Naugle, 2010). The Question of Meaning/Purpose- We as Christians believe that our purpose is to do the will of God. John 15:16(ESV Bible) we are appointed to go and bear fruit. In Matthew 28:19(ESV Bible) we are commanded to go and make disciples. Through-out the Bible, God has charged us with being the salt of the earth and light of the world, He has commanded us to go and compel them to come so that his house may be filled. As we can see our main purpose is to live a life that exemplifies Christ and leads others to Him. The Question of Morality- Romans 5:12-14(ESV Bible) sin entered the world. Romans 3:23(ESV Bible) we all have sinned and fall short of the Glory of God. God is the ultimate standard of morality and because of the depravity of man we cannot live up to His standard, thus needing redemption through the blood of the Lamb, Jesus Christ. The Question of Destiny- it is clear throughout the Bible about our final destination. Johnà 3:16-17, John 5:13-14 (ESV Bible) and many other verses in the Bible make it clear that if we do not put our faith and trust in God and accept the gift of salvation that we will not spend eternal life with Him but rather burn in the lake of fire. God also makes it clear that the gift of salvation cannot be earned Eph. 2:8-9. Part III A biblical worldview should influence the way you think about, treat, and speak to others on a daily basis because we should treat people how we would want to be treated, Matthew 7:12 (ESV Bible). If we are to believe that God created us in His likeness and He commands us to go out and make disciples for Him then we would have to also believe that we should think, treat and speak to others in a Christ like manner on a daily basis. To not do so would make us as Christians look hypocritical in the eyes of non-believers. â⬠¦.treat/interact with the environment and non-human creation? In Genesis 1:26(ESV Bible) God commands us to have dominion over the earth and subdue it. This does not mean that we can ravage the land and kill all the creatures on it. We are to be stewards of what God has given us and that includes the earth and the creatures on it. References Keener, D. (n.d.). What is a worldview?. Retrieved from http://www.dkeener.com/keenstuff/wv.html Lefebvre, M. (2011, April 02). Worldviews-christian. Retrieved from http://warrantedbelief.wordpress.com/2011/04/02/worldviews-christianity/ Naugle, D. (2010, February 14). Developing a biblical worldview. Retrieved from http://www.colsoncenter.org/the-center/columns/indepth/14423-developing-a-biblical-worldview Tackett, D. (n.d.). Whatââ¬â¢s a christian worldview?. Retrieved from http://www.focusonthefamily.com/faith/christian_worldview/whats_a_christian_worldview.aspx Weider, L., & Gutierrez, B. (2011). Consider. Virginia Beach: Academic Publishing Services, Inc.
Saturday, January 4, 2020
Personal Statement And American Eagle Campaign Essay
Motivation drives us to accomplish our goals in life. A simple sentence such as I can get through this day. or I can become president. turns into the driving factor that helps us reach our destination. We all have used the I can statement and American Eagle has taken that statement to the next level in their #WeAllCan Campaign. The minute long video features a cast of celebrities in different settings throughout New York like Coney Island wearing a casual style of clothing. Black and white scenes intertwine with color scenes throughout the video, with even a vintage style of film shown. Through the credibility of the cast, the American Eagle Campaign effectively appeals to a target audience of millennials. The campaign uses pathos to create a cause of individuality and speaking out, but only uses those celebrities in a stereotypical way to sell the brand of clothes. This advertisement features a group of well-known millennials from our generation that give an immense amount of credibility to the commercial. It has role models of social media, music, television, and the fashion industry. Some actors that appear frequently are Troye Sivan, an out of the closet gay musician, Hailee Steinfeld, famous actor of Blackish, and Cody Christian, the recurring actor from Pretty Little Liars. This cast shows individuality and the new generation by having different races, sexual orientation, and gender. The ethos in the video attracts not only heteronormative buyers with theShow MoreRelatedBusiness Law Answers4935 Words à |à 20 Pagesthis response with witnesses; sworn statements: a motion of summary judgement ï ¿ ½ Unit 2 Review: 1. In tort law, an actor who knows the substantial certainty that certainï ¿ ½consequences will result from an act has intent. TRUE 2. False imprisonment is a tort only if confinement is unjustified. TRUE 3. 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